Perspectives and expectations in structural bioinformatics of metalloproteins

Minimal Functional Sites in Metalloproteins and Their Usage in Structural Bioinformatics

Metal ions play a functional role in numerous biochemical processes and cellular pathways. Indeed, about 40% of all enzymes of known 3D structure require a metal ion to be able to perform catalysis. The interactions of the metals with the macromolecular framework determine their chemical properties and reactivity. The relevant interactions involve both the coordination sphere of the metal ion a...

Perspectives in paramagnetic NMR of metalloproteins.

NMR experiments and tools for the characterization of the structure and dynamics of paramagnetic proteins are presented here. The focus is on the importance of (13)C direct-detection NMR for the assignment of paramagnetic systems in solution, on the information contained in paramagnetic effects observed both in solution and in the solid state, and on novel paramagnetism-based tools for the inve...

Bioinformatics to Biostochastics: Statistical Perspectives and Tasks Ahead

Bioinformatics is an emerging field of science emphasizing the application of mathematics, statistics, and informatics to study and analysis of very large molecular biological (mostly, genetic and genomic) systems (data sets). In a comparatively broader setup of large biological systems without necessarily having a predominant genetic undercurrent, and having genesis in biometry to biostatistic...

X-ray structural studies of some metalloproteins

Metalloproteins are an important class of proteins and perform a variety of biological processes. They are ideally suited for Synchrotron Radiation studies. In particular, X-ray region of the spectrum has been very effectively exploited not only for crystallographic structure determinations but X-ray absorption fine structure (XAFS) and more recently X-ray solution scattering techniques have al...

Bioinformatics III: Structural Bioinformatics and Genome Analysis